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In fexofenadine excessive drug report is unusual, and therefore affects not very well-founded. Death has no place in testing in the mouse, at 5000 mg / kg, is 110 times, most significantly in doses that are recommended for adult. Further studies did not indicate death in the mouse to the same centralism, in respect of which 400 times the dose recommended for adults. To study the scope of a person only 800 milligrams doses, primarily in the two 690 milligram doses in a month, do not have significant adverse clinical effects when compared with placebo. Causes哌啶Productions, the two phenyl groups was first introduced using Grignard respond broadcasts for higher ethanol. And then at the amine group alkylate with aldehydes, which protects, and then restores aldehydes in deprotection with acid. I molecular causes of surplus piece by double alkylation carbanion iodomethane to obtain from nitrile. Nitrile groups then hydrolisis to hydroxy acid. In aromatic hydroxyl bromide production is lithiated organolithium compound is perhaps the single gives (in the workup for a piece of aldehydes later) fexofenadine.